Of the options mentioned in the question, the only one that Isaac and Rebecca didn't suffer was marital infidelity. Isaac who was one of the sons of Abraham was 40 years old, when he got married with the beautiful Rebecca. After they got married and realized they were having issues to get pregnant, Isaac prayed to God for his infertile woman. And because of this, Rebecca got pregnant and had twins, Esaú and Jacob. (Genesis 25,21)
Later when the twins grew up, and Esaú was 40 years old he married 2 Ca' naan women; Judit and Basemat who didn't worship Jehovah what was a conflict whit Isaac and Rebecca's beliefs and caused a great bitterness. (Genesis 26,35)
And finally when Issac was about to pass away, he got blind. (Genesis 27,1)