Answer:
Large numbers died from diseases that they caught from Europeans.
Step-by-step explanation:
One of the biggest problems that the Native Americans faced with the arrival of the Europeans was the fact that the Europeans brought with them various diseases that the Native Americans had never been exposed to. This meant that, upon contact with them, many were infected by diseases to which they had no immunity. A large number of them died, with catastrophic consequences for their culture and way of life.