While animals such as sheep, cows, pigs and horses were available in the old continent, the Americas lacked large animals that could be domesticated. This had an important impact on the civilizations that developed there.
On the one hand, Europe benefited from this as the animals were useful for farm work. The presence of large animals also allowed many means of transportation to develop. This meant that production was generally less efficient in the Americas. On the other hand, the Americas had some advantages, as the lack of animals meant that many diseases that originated in these animals were not common among the people of the Americas.