There's multiple reasons why the conquistadors were so successful in colonizing Central America, and some of them are:
- They were seen as Gods;
At the beginning, the Spanish settlers were seen by the natives as Gods, and this was mainly due to their white skin, and the way they came with their boats.
- Possessed superior weaponry;
The Spanish had gunpowder and guns, as well as cannons, while the natives did not had any fire weapons.
- Made cleaver alliances;
They used the situation of tribes hating each other, so they made alliances with some of them which served them very well.
- Brought diseases;
The native people were not immune to certain diseases the Europeans brought with them, so they were dying from seeming harmless things for European standards.