The 4th option is the correct answer.
Step-by-step explanation:
Here we will place the opposite of the number of the divisor in the top left box. Now we will bring down the coefficient of the squared term or 2. Now, we will multiply the number in the top left box or 5 with the times of the coefficient of the squared term. This gives 10 and we will place 10 in the second column. This column now contains -1 and 10 and adding these we get 9. Now we will multiply 5 with the result of the second column or 9 to get 45, We will place 45 in the third column which already has 4, and adding both we get 49.