Question

Marfan syndrome is a genetic disorder that affects connective tissue, leading to abnormal skeletal development, lens deformities in the eyes, and heart complications. The disorder is caused by a mutation in the FBN1 gene. The following DNA sequences show a section of the FBN1 gene in an unaffected individual and an individual with Marfan syndrome.

Unaffected individual: CCG-CCG-CTT

Individual with Marfan syndrome: CGG-CCG-CTT

Marfan syndrome is an autosomal dominant disorder, so the mutation that causes it is a somatican inherited

mutation. According to the DNA sequences shown, Marfan syndrome can be caused by a deletionsubstitutioninsertion mutation in the FBN1 gene. This mutation is likely a beneficialneutralharmful mutation.

Answer 1

There are 3 boxes to fill. I just took the test and got it right.

1. an inherited

2. substitution

3. harmful

Step-by-step explanation:

Answer 2

Marfan syndrome can be caused by a substitution mutation in the FBN1 gene. This mutation is likely a harmful mutation.

From the DNA sequence of unaffected individual and

individual with Marfan syndrome we can see that C is substituted with G. Each parent with the Marfan syndrome has a 50% risk of passing the genetic defect on to offspring because of its autosomal dominant nature, so the mutation is harmful.