Step 1. Use Multiplication Distributive Property
-3 * 2^4x^4(4x^5y)^2
Step 2. Simplify 2^4 to 16
-3 * 16x^4(4x^5y)^2
Step 3. Use Multiplication Distributive Property
-3 * 16x^4 * 4^2(x^5)^2y^2
Step 4. Simplify 4^2 to 16
-3 * 16x^4 * 16(x^5)^2y^2
Step 5. Use the Power Rule
-3 * 16x^4 * 16x^10y^2
Step 6. Take out the constants
-(3 * 16 * 16)x^4x^10y^2
Step 7. Simplify 3 *16 * 16 to 768
-768x^4x^10y^2
Step 8. Use the Product Rule
-768x^4 + 10y^2
Step 9. Simplify 4 + 10 to 14
-768x^14y^2