Parathyroid hormone is secreted from parathyroid glands. Parathyroid hormone increases calcium levels in the blood when they are too low. Whereas as calcitonin is a hormone secreted by the parafollicular cells of the thyroid gland. It works antagonistically to the parathyroid hormone. This means that calcitonin reduces calcium levels in the blood when it is high. It is, therefore, the secretion of both calcitonin and parathyroid hormone is determined by the level of calcium in the blood.