The meaning of the phrase "thou art wedded to calamity” is that You often have disaster around you.
This dialogue has been said by Friar Lawrence to Romeo in the play “Romeo and Juliet.” sufferings have been personified as a human being with whom Romeo has completed the steps of marriage. It was after meeting and falling in love with Juliet that Romeo's life got surrounded by difficulties. A metaphor has been used in the line which compares Juliet with 'calamity.'