Answer:
He has lost confidence in his own judgment because of his involvement with Mr. Hyde.
Step-by-step explanation:
According to the excerpt from The Strange Case of Dr. Jekyll and Mr. Hyde, Robert Louis Stevenson, there is a dialogue between Mr Hyde and Utterson where Mr Hyde asks for Mr Utterson's advice about a letter he received which he was not sure he wanted to show to the police.
Therefore, the inference about Dr. Jekyll that is best supported by evidence from the passage is that He has lost confidence in his own judgment because of his involvement with Mr. Hyde.