The digit 5 in 4521 has a value that can be found by setting the other digits to zero. It is 500.
The digit 5 in 2615 has a value that can be found by setting the other digits to zero. It is 5.
500 is 100×5.
The digit 5 in 4521 has a value that is 100 times the value of the digit 5 in 2615.