The three most advanced civilizations to have been developed in the western hemisphere were Incas, Mayas, and Aztecs.
The Inca empire was the largest empire in pre columbian America. Its political and administrative structure was the most sophisticated among native peoples in the America.
The Maya civilization was a Meso-american civilization developed by the Maya peoples. It was known for its hieroglyphic script, art, architecture, mathematics, calendar, and astronomical system.
The Aztecs were also a Meso-american culture that flourished in central Mexico in the post-classic period. The Aztecs included different ethnic groups of central Mexico who dominated large parts of Meso-america.