In sickle cell anemia, there is a replacement in the amino acid sequence of hemoglobin of glutamic acid by valine. what is the difference between glutamic acid and valine?

Valine is a hydrophobic amino acid used for biosynthesis of proteins. It is essential in humans, meaning the body cannot synthesize it and it must be obtained from the diet.

Glutamic is a hydrophilic amino acid used by almost all living beings in the biosynthesis of proteins. It is non-essential in humans and the body can synthesize it.

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In sickle cell anemia, there is a replacement in the amino acid sequence of hemoglobin of glutamic acid by valine. what is the difference between glutamic acid and valine?

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