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If atp hydrolysis took place in an acidic solution such that it no longer carried negative charges, how would you predict that the free energy released would change?

User Errorpro
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The correct answer is that less free energy will be released.

This would happen because, usually the high negative charge density associated with the three adjacent P (phosphate) units of ATP destabilizes the molecule, making it higher in energy. In an acidic solution that no longer carries negative charges, ATP molecule will have less energy.

User Suhas Deshpande
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