1. Rotation by 180° (clockwise or anti-clockwise) about the origin has a rule:
(x,y)→(-x,-y).
Then
(-4,-10)→(4,10).
2. Translation 1 unit to the right has a rule:
(x,y)→(x+1,y).
Then
(4,10)→(5,10).
3. After rotation and translation the image of point (-4,-10) is point (5,10).
Answer: (5,10).