Central America (also referred to as Mesoamerica) and the Caribbeans did not had any contact with Eurasians and Africans because they were not connected by land with those continents, but instead separated by vast ocean waters, and the people from both sides were not even aware of the existence of the others.
Because of the isolation, the people from Central America and the Caribbeans managed to develop their own unique cultures, traditions, religions, way of living, architecture, organization, that were unlike any others in the rest of the world.