Question

Research shows that neurofibrillary tangles associated with the disintegration of microtubules are the primary cause of alzheimer's disease. if microtubules disintegrate, what then might happen to brain cells?

Answer 1

Without microtubule, the brain cell will die

Step-by-step explanation:

Microtubules are very essential for determining the the shape of the cell. Physically, they help in the movement of substance with in cells. The major function of microtubule is to hold different parts of the brain cells in intact position and also provide shape to the long elongated brain cell. Without microtubule, the brain cell may become lose and it may also lose its shape. It keeps the distant part of the brain cells alive and without it the brain cell may become dead.

Answer 2

The healthy human brain consists of billions of neurons. These neurons process the information and transmit the information in the form of various chemical and electrical signals. The neurons help exchange the information between the various parts of the brain, and between brain and the various parts of the body through the peripheral nervous system. The Alzheimer's disease disrupts this communication, resulting in the loss of function of neurons and eventual death of the neuronal cells.

Neurofibrillary tangles are abnormal accumulation of the tau proteins inside the neuron. The tau proteins are present in the ends of the microtubules that form the skeleton of the neurons. When the tau proteins detach from the microtubules and agglomerate, it leads to the tangling of the microtubule fibres inside the cell. This tangle hampers the transmission of signal through the body of the neuron.