Assuming none of the factors is zero, if an odd number of the factors of a multiplication problem have negative signs, then the product will be negative. Otherwise, the product is positive.
Assuming the dividend of a division problem is non-zero, the quotient wil be negative if the signs of the dividend and divisor are differnt. Otherwise the quotient is positive.
In short, if a multiplication or division problem involves an odd number of minus signs, the result will be negative. Otherwise, the result is positive.