The New England, Middle, and Southern colonies had several similarities including:
1) All controlled by England- The 13 colonies in North America were all under the control of the English government up until America declared independence in 1776.
2) All had some form of agriculture/farming- Even though the products were different (i.e. tobacco in the South, grain in the Middle colonies), there was at least some form of farming done in all 13 colonial regions.
3) All of these regions were developed in order to make England money- This is part of the system known as mercantilism. Essentially, all 13 colonies existed in order to provide natural resources and profit for England.
4) All three regions had slaves at some point.