Answer:
King Charles V of Spain gained control of the Holy Roman Empire in 1519.
Step-by-step explanation:
King Charles V of Spain was a descendant of the Habsburg house. From 1506 to 1555 he was the lord of all the Dutch regions (since 1543), from 1516 to 1556 as Charles I king of Spain and from 1519 to 1556 as Charles V, Emperor of the Holy Roman Empire.
The countries over which he ruled together formed the largest European empire since that of Charlemagne. In fact, his entire empire, including the American and Asian territories, was even larger than the former Roman Empire and can rightly be called one of the first empires of the New Age. Moreover, with the actual power of his home countries, Charles V was the last Holy Roman emperor who had the opportunity to assert his universal authority. At the European level, he successfully fought off the attacks of the Ottoman Empire. The virtually permanent struggle with France remained on undecided balance.