Answer: germline mutation
Step-by-step explanation:
Cystic Fibrosis (CF), also known as a hereditary disease that affects several organs of the body, mainly the pancreas and the lungs. Patients with Cystic Fibrosis have two altered genes, who inherited one from the father and one from the mother. The disease has not yet been cured, but the diagnosis and treatment improve the patients' quality of life. The disease-gene (CFTR) produces a change in the function of the protein that regulates the transport of chlorine into epithelial cells. As a consequence, the secretions are more viscous, obstructing the channels of the exocrine glands in the pancreas, lungs, intestine, liver, and testes. As the mutation occurs in (reproductive) germ cells, or in tissues that will give rise to these cells, and it is consequently passed on to subsequent generations it is known as germline mutation .