Question

Select the compounds that cannot undergo friedel crafts alkylation. check all that apply. check all that apply. aniline phenol ketones halobenzenes benzene nitrobenzene anisole benzensulfonic acid toluene

Answer 1

Compounds like aniline, phenol, nitrobenzene, and benzensulfonic acid cannot undergo Friedel-Crafts alkylation due to their strong activating or deactivating groups, which are either reactive towards AlCl3 or deactivate the aromatic ring, making the reaction unfavorable.

Step-by-step explanation:

The compounds that cannot undergo Friedel-Crafts alkylation include those that have groups which either deactivate the aromatic ring towards electrophilic substitution or those that can be destroyed by the strong acids (such as AlCl3) used in the Friedel-Crafts alkylation process. Specifically:

• Aniline and phenol have -NH2 and -OH groups, respectively, which are strongly activating towards electrophilic aromatic substitution but will react with AlCl3, rendering them unsuitable for this reaction.
• Nitrobenzene contains a -NO2 group which is a strong deactivator for the ring, making the aromatic compound resistant to Friedel-Crafts alkylation.
• Benzensulfonic acid has a -SO3H group which is also a strong deactivator and can be affected by the acidic conditions of the reaction.

Ketones, halobenzenes, benzene, anisole, and toluene are all capable of undergoing Friedel-Crafts alkylation because they either have groups that are electron-donating but not excessively reactive towards AlCl3 or, in the case of benzene, have no substituents that would interfere with the reaction.

Answer 2

Freidal craft reaction is the attack of a carbon or carbon chain on aromatic ring with the help of anhydrous AlCl3 to produce alkylated benzene ring.

Only ketone not be able to undergo friedal craft reaction as, it is not aromatic compound whereas all the given reactants are aromatic and gives friedal craft reaction.