Since its called Wrinkle in time, Some people would always start at the begin, To Let people know what is happening in this Novel, Like lets say..
"A Wrinkle in time, My farther always said." is a Quotation
"Wrinkle in time"
The setting would Be preferred as, You were reading your farther's old Journal of his Journeys since your farther Was a Person who kept records of his Amazing Journeys he has been on when you were not even born, Sometimes you wished you could have seen him, But the last word your farther ever said to you was "Don't, Worry I'll Come back I promise."
Just as... the setting can be in certain places, As in a bedroom,Bathroom and place you decide to pick, It's just like a book. But to be more preferred (read above)