The continent of Africa benefitted least from the Columbian Exchange. Despite receiving goods, weapons, and other valuable resources from Europe, millions of Africans were enslaved. The enslavement of Africans caused significant damage to the social and economic structure of the continent.
Europe benefitted the most from the Columbian Exchange. This continent received foods that became staples in their diet including potatoes. Along with this, Europeans also recieved tobacco from the New World. Tobacco was a popular substance used by Europeans due to this trade. Lastly, European countries got to spread their power to a completely new continent, allowing them to gain new natural resources never seen before.