Hello!! Sickle cell anemia is genetic that can be passed down by the parents carrying the gene, like this diagram. Your best answer would be “A male having the disease” because whenever the parents have children, a male will be completely normal, have two girls who carry the gene, and the male who has the disease. Whenever things are half shaded, it means that they are carrying the gene. Whenever things are not shaded at all means that they do not carry the gene. Whereas, when the fourth box is completely shaded, it means that they have the disease/trait. I hope this helps!! Have a great day!!