Answer:
The correct answer is option B. "It set Catholics and Protestants against each other throughout the empire".
Step-by-step explanation:
The Protestant Reformation was a 16th century European movement which main goal was to cause major changes in the practices of the Roman Catholic Church. This Reformation caused that Catholics and Protestants fought each other to gain control of the empire. These conflicts were part of what is known as the European wars of religion, which extended up to the early 18th century.