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(-1,2p³q)(10p²r²)=
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User Kasheftin
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For this case we have the following expression:

(-1.2p^3q)(10p^2r^2)
When making multiplication, the first thing you should keep in mind is the following property:
Same basis, the exponents are added.
We have then:

-12p^(3+2)r^2q
Rewriting we have:

-12p^(5)r^2q
Answer:
The simplified expression is given by:

-12p^(5)r^2q
User Jose Garrido
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