Answer:
276
Explanation:
There are three types of words we're allowed to form: vowel-consonant, vowel-vowel, and consonant-vowel. We treat these as separate cases.
The first type of word (vowel-consonant) can be formed in $6\cdot 20=120$ ways, since we have $6$ choices for the first letter and $20$ choices for the second letter.
The second type of word (vowel-vowel) can be formed in $6\cdot 6 = 36$ ways.
The third type of word (consonant-vowel) can be formed in $20\cdot 6 = 120$ ways.
Adding up all these possibilities, we have $120+36+120 = \boxed{276}$ possible two-letter words with at least one vowel.
Solution #2
If we ignore the requirement to have at least one vowel, then we have 26 choices for each letter, making $26\cdot 26 = 676$ two-letter "words". Now we eliminate the $20\cdot 20 = 400$ words whose letters are both consonants. This leaves $676-400=\boxed{276}$ words with at least one vowel.