Answer:
C. Native American populations were greatly reduced by disease.
Step-by-step explanation:
When the settlers established themselves in America, they were carrying diseases that the natives had never been exposed to. This caused them to get sick and die in huge numbers. In turn, this meant that the colonies were in need of cheap labour, and there was not enough people to provide it. Their first solution was indentured servitude, which eventually progressed in slavery, later associated with African ancestry.