Final answer:
Patrick Henry would most likely be aligned with the Anti-Federalists in the fight over the ratification of the US Constitution.
Step-by-step explanation:
The speaker who would most likely be aligned with the Anti-Federalists in the fight over the ratification of the US Constitution is Patrick Henry. He was the chief spokesman for back-country farmers in Virginia who feared the powers of the new federal government. Henry and the Virginia Anti-Federalists believed that the states would not retain their separate rights or powers without using the individual state's name in the Constitution.