Question

In infectious mononucleosis what does the monospot test detect

Answer 1

In infectious mononucleosis (IM), the monospot test detect the IgM. Infectious mononucleosis is also called the kissing disease. It is caused by the virus Epstein-Barr virus, however other virus may cause the disease. IgM is present on the B cells and mainly functions in the control of B-cell activation. 

Answer 2

In infectious mononucleosis the monospot test detects heterophil antibodies. The mononuclear spot test or monospot test is a form of the heterophile antibody test for a rapid detection of infectious mononucleosis due to Epstein–Barr virus (EBV). The test is specific for heterophile antibodies produced by the human immune system in response to EBV infection. About 70%–80% of patients with infectious mononucleosis produce these heterophile antibodies, which are not specific for EBV infection but are good predictors.