The correct answer to this open question is the following.
Although there are no options attached, we can answer the following.
What European powers wanted in the Americas was the many raw materials and natural resources such as gold and silver. European monarchs like the monarchs of Spain wanted to exploit these resources to get more wealthy.
They achieved this by conquering and colonizing the territories over the Mesoamerican Indians, as was the case of Spain, or over the Native American Indians, as was the case of the British colonies that arrived at the East Coast of North America to found colonies such as the Jamestown, Virginia colony, in 1607 and the other twelve.
These European colonists also brought with them many diseases that wipe out almost the indigenous population with diseases such as smallpox, malaria, chickenpox, influenza, and cholera.