Question

For each of these cofactors, explain its chemical function and give an example of a particular enzyme that would use it: TPP, PLP, biotin, FAD, NADPH

Answer 1

The function of the given cofactors are listed below.

Step-by-step explanation:

TPP or thymine pyrophosphate TPP is used as cofactor during Pentose phosphate pathway and de carboxylation of pyruvate.

PLP or pyridoxal phosphate PLP is used as coenzymes in trans amination reaction.

Biotin or vitamin B7 Biotin is used as coenzyme during one carbon transfer reaction For example pyruvate to oxaloacetate.

FAD or Flavin Adenine dinucleotide FAD is used as co enzyme in many metabolic reactions such as fatty acid oxidation, TCA cycle.

NADPH NADPH is used as coenzyme to minimize the toxic effect of reactive oxygen species.

Co enzymes Enzymes

1 TPP 1 Trans ketolase

2 PLP 2 Alanine aminotransferase

3 Biotin 3 Pyruvate carboxylase

4 FAD 4 Acyl CoA dehydrogenase

5 NADPH 5 Glutathione reductase.