Final answer:
EnCase and AccessData's Forensic Toolkit (FTK) are two programs that can import indexed versions of the NIST NSRL of MD5 hashes to assist in digital forensic investigations by excluding known files from search results.
Step-by-step explanation:
The program that is often used for managing and searching within the National Institute of Standards and Technology's National Software Reference Library (NIST NSRL) database of MD5 hashes is EnCase. This forensic software allows professionals to import the hash sets provided by the NIST NSRL, which can then be used to identify known files from operating systems and applications.
AccessData's Forensic Toolkit (FTK) is another program that supports the integration of NIST NSRL hash sets. These tools are crucial in the field of digital forensics, as they help in streamlining the analysis process by filtering out known safe files and highlighting only the data that may be pertinent to an investigation.