Question

How does histone acetylation affect chromatin?

A) It loosens the chromatin and allows increased transcription.
B) It allows DNA to become resistant to damage.
C) It helps the histones have a greater affinity for DNA.
D) It inhibits DNA replication by making it more difficult to separate the DNA strands.
E) It causes the chromatin to become more condensed in preparation for metaphase.

Answer 1

The correct answer is option A.

Step-by-step explanation:

The histone acetylation catalyzed by histone acetyltransferases and deacetylation catalyzed by histone deacetylases performs a significant role in the regulation of the expression of genes in eukaryotes. Histone acetylation diminishes the affinity of histones towards DNA leading to relaxing or decondensation of chromatin and becomes accessible to the transcriptional apparatus and to perform transcription.

It can be stated that histone acetylation is related to expression or gene or activation and histone deacetylation is related to the inactivation of gene or repression.