Question

A mutation in the gene encoding the enzyme Mitogen Activated Protein Kinase Kinase (MAPKK) produces a constitutively activated form of MAPKK. That is, the mutation produces a MAPKK enzyme that is always active, leading to uncontrolled cell division and tumor formation. On a cellular level, which one of the following would be helpful in reducing the harmful effect of the MAPKK gene mutation?

A) Increasing the activity of Mitogen Activated Protein Kinase (MAPK) in the cell.
B) Inhibiting the activity of Mitogen Activated Protein Kinase (MAPK) in the cell.
C) Adding ligand for the Epidermal Growth Factor Receptor (EGFR).
D) Inhibiting activity of the monomeric G-protein, RAS.
E) Inhibiting the activity of Mitogen Activated Protein Kinase Kinase Kinase (MAPKKK).

Answer 1

B) Inhibiting the activity of Mitogen Activated Protein Kinase (MAPK) in the cell.

Explanation;

you can reduce the harmful effects of MAPK gene mutation by inhibiting the activity of MAPK, which is helpful in regulating the cell proliferation and and differentiation by activating kinase cascades pathway. so by stopping its activity in cancer cells, will stop proliferation and reduce the effects of mutation.