Question

Three reactions involved in the metabolism of different nucleotides are written below. Complete the reactions by moving the substrates and products to the appropriate places. The abbreviation HGPRT is used for the enzyme hypoxanthine-guanine phosphoribosyltransferase; PRPP is used for phosphoribosyl pyrophosphate. Not all labels will be used.T

Answer 1

These are the completed reactions using the provided substrates and products:

• PRPP + ATP (thymidine kinase) → thymidine monophosphate + ADP
• Guanine + PRPP (HGPRT) → GMP +
  `PP_i`
• AMP + ATP (adenylate kinase) → 2ADP

What occurs in this reaction?

In the first reaction, thymidine kinase catalyzes the phosphorylation of thymidine to thymidine monophosphate using ATP. The second reaction, mediated by HGPRT, involves the transfer of a phosphoribosyl group from PRPP to guanine, forming GMP and releasing pyrophosphate (
`PP_i`).

The third reaction, facilitated by adenylate kinase, converts AMP and ATP into 2ADP. These reactions are crucial in nucleotide metabolism, contributing to DNA synthesis and cellular processes. Each enzyme plays a specific role, and their coordinated activity maintains nucleotide balance for essential cellular functions.

Complete question:

Three reactions involved in the metabolism of different nucleotides are written below. Complete the reactions by moving the substrates and products to the appropriate places. The abbreviation HGPRT is used for the enzyme hypoxanthine-guanine phosphoribosyltransferase; PRPP is used for phosphoribosyl pyrophosphate. Not all labels will be used.

_____ + ATP (thymidine kinase) ---> ____+ ADP

____ + ____ (HGPRT) ----> _____ + PP_i

____ + ____ (adenylate kinase) ----> 2ADP

PRPP

AMP

ATP

dUMP

phosphate

GDP

GMP

thymidine

ADP

dTMP

guanine

Answer 2

as the question is incomplete i have attached the full question with solution. see attachment. This question is matching pair therefore i compiled it in a picture format for better understanding.