Question

The benefit of measuring the initial rate of a reaction V₀ is that at the beginning of a reaction: A) [ES] can be measured accurately. B) changes in [S] are negligible, so [S] can be treated as a constant. C) changes in Km are negligible, so Km can be treated as a constant D) V₀ =
`V_(max)`. E) varying [S] has no effect on V₀

Answer 1

C) changes in Km are negligible, so Km can be treated as a constant

Step-by-step explanation:

Hello,

Biochemical reactions have been widely modeled by Michaelis through His well-known equation:

`Vo=(V_(max)[S])/(Km+[S])`

Thus, in order to correctly assure the value of the initial rate of the reaction allows the calculation of Km, therefore changes in Km are negligible, so Km can be treated as a constant as long as it is the substrate concentration at half of the maximum rate, in fact, Km is known as the Michaelis constant.

Best regards.