Question

The information in pedigrees that is useful for mapping disease genes is sometimes limited. This pedigree shows segregation of neurofibromatosis, which is a fully-penetrant, autosomal dominant condition, and a single nucleotide polymorphism, SNP3. Why are the genotypes of the children noninformative for determining the degree of linkage between the disease-causing gene NF and SNP3?

Answer 1

Explanation:Most complex diseases arise due to combinations of genetic factors.

in which different subsets of individuals develop a given disease due to different sets of genetic factors.