Question

The pentose phosphate pathway (PPP) is localized to the cytosol.

Why is the localization of the PPP important?
O ATP production uses the NADPH generated by the PPP.
O Nucleotide synthesis uses the ribose 5‑phosphate generated by the PPP.
O Fatty acid synthesis uses the NADPH generated by the PPP.
O Reduced glutathione is formed using NADPH generated by the PPP.
O Fatty acid β-oxidation uses the FAD generated by the PPP.

Answer 1

The localization of the PPP in the cytosol is crucial for providing NADPH for fatty acid synthesis and keeping glutathione reduced, as well as supplying ribose 5-phosphate for nucleotide synthesis.

Step-by-step explanation:

The localization of the pentose phosphate pathway (PPP) to the cytosol is important because it is closely connected to numerous cellular processes that occur in this part of the cell. The PPP produces NADPH, which is used for fatty acid synthesis and in maintaining glutathione in a reduced state (GSH), which is crucial for protecting cells against oxidative damage. In addition, the PPP generates ribose 5-phosphate, which is a necessary precursor for the synthesis of nucleotides. Therefore, the cytosolic localization of the PPP is significant as it ensures NADPH and ribose 5-phosphate are readily available for these critical biosynthetic pathways.