Question

The A159E mutation causes an A amino acid to be replaced with an E amino acid (their structures are shown here). What type of mutation is the A159E mutation?

Answer 1

Substitution

Step-by-step explanation:

Mutations can simply be defined as change in the structure of a gene. Mutation can be of different types. These include, but not limited to:

• Insertion: This involves the insertion of extra base pairs into a DNA
• Deletion: Loss of DNA section
• Substitution: When a nucleotide base gets substituted with another base.

Substitution of a base can lead to coding of different amino acid and hence, protein. It can also lead to coding of the same amino acid, otherwise known as silent mutation. Base substitution can also lead to the amino-acid-coding codon becoming a stop codon, leading to an incomplete protein.

The correct answer is substitution.