Final answer:
Proteins made by free ribosomes in the cytoplasm are used within the cytosol, while proteins made by ribosomes bound to the endoplasmic reticulum are inserted into organelles or secreted from the cell.
Step-by-step explanation:
Proteins made by both free ribosomes and ribosomes bound to the endoplasmic reticulum have different destinations within the cell. Proteins made by free ribosomes in the cytoplasm are generally used within the cytosol of the cell. They do not go through the Golgi apparatus. On the other hand, proteins made by ribosomes bound to the endoplasmic reticulum are either inserted into the ER and other organelles or secreted from the cell. They undergo modifications and are transported through the Golgi apparatus before reaching their intended destinations.