Answer:
The Ninety-five Theses led to the Reformation, a break with the Roman Catholic Church that previously claimed hegemony in Western Europe. Humanism and the Renaissance therefore played a direct role in sparking the Reformation, as well as in many other contemporaneous religious debates and conflicts.
Step-by-step explanation:
During the Renaissance, people increasingly began to see the world from a human-centered perspective. This had a powerful impact upon religion. Increasingly, people were paying more attention to this life rather than the afterlife. Eventually, humanism brought about a spirit of skepticism.