Final answer:
If trying a different mouse does not fix the problem, it is likely that the issue lies with the motherboard's chipset. The chipset is responsible for managing communication between different hardware components on the motherboard. In this case, the portion of the chipset that handles USB connectivity may be causing the problem.
Step-by-step explanation:
Since both mice are not responding, it suggests that the problem is not specific to the mouse itself, but rather with the communication between the mouse and the motherboard. The USB controller within the chipset is responsible for managing USB devices like mice, so a malfunction in this portion can result in unresponsive mice.