Question

The hyperalgesia that is common in phantom limb pain could potentially be blocked if a new drug was developed that could prevent (without triggering any side-effects) the ______.

a) binding of enkephalins to NMDA receptors
b) diffusion of calcium ions through NMDA receptors
c) release of enkephalins diffusion of enkephalins
d) across synaptic clefts

Answer 1

Answer: The answer is B- Diffusion of calcium ions through NMDA receptors.

Step-by-step explanation:

Phantom limb pain (PLP) is a painful sensation experienced after the loss or amputation of a limb. The limb is no longer there but the individual can still feel real and severe pains in the limb. This occurs soon after surgery.

NMDA is a receptor for Glutamate which is an excitatory neurotransmitter. The activation of NMDA receptors are associated with hyperalgesia which is an abnormally heightened sensitivity to pain.