Question

Some bacteria from the intestinal microbiota work their way into the intestinal wall and start

to spread through the circulation. Many of these bacteria are stopped by MALT, while many
more are destroyed by
A) Hepatocytes.
B) Hepatic macrophages.
C) The walling-off action of the greater omentum.
D) Megakaryocytes.

Answer 1

The correct answer is B) Hepatic macrophages.

Step-by-step explanation:

Hepatic macrophages are called kupffer cells that are specialized phagocytic cells which kill microbes non-specifically. They are present in the lumen of liver sinusoid and are among the first immune cell that encounters the gut bacteria and their endotoxin during any gut infection.

Under shear force, kupffer cells capture the gut bacteria from hepatic sinusoids, engulfs that bacteria and digest it. Hepatic macrophage kills thousand of bacteria non- specifically during its lifetime. So many intestinal bacteria that starts to spread through the circulation are destroyed by hepatic macrophages. So the correct answer is B.