Question

Which of the following sequences shows a frameshift mutation compared to the wild-type mRNA sequence?

A) wild-type 5’-AUGCAUACAUUGGAGUGA-3’ mutant 5’-AUGCAUGUGACAUUGGAGUGA-3’
B) wild-type 5’-AUGCAUACAUUGGAGUGA-3’ mutant 5’-AUGCAUACAGAGUGA-3’
C) wild-type 5’-AUGCAUACAUUGGAGUGA-3’ mutant 5’-AUGCAUACGUUGGAGUGA-3’
D) wild-type 5’-AUGCAUACAUUGGAGUGA-3’ mutant 5’-AUGCAUACAUCUGGAGUGA-3’

Answer 1

D) wild-type 5’-AUGCAUACAUUGGAGUGA-3’ mutant 5’-AUGCAUACAUCUGGAGUGA-3’ is the right answer

Step-by-step explanation:

frame shift mutation is that mutation in which change in nucleotide sequence ( deletion or insertion) changes the encoding amino acid sequences.

wild-type 5’-AUGCAUACAUUGGAGUGA-3 encode MHTLE- protein sequence while

5’-AUGCAUACAUCUGGAGUGA-3’ encode MHTSGV.

in this option there is clear difference between the encoding amino acid sequence

.in option A and B, there are addition and deletion of amino acids because of addition of nucleotide.