Question

Which statement regarding lysosomal storage diseases is true?

a). A gene defect makes lysosomes unable to store degraded compounds.
b). Accumulation of stored iron results in cell, tissue, and organ dysfunction.
c). Defective enzymes result in the accumulation of potentially toxic substances.
d). Mutations in the genes coding for different types of collagen produce substances that are toxic to brain cells.

Answer 1

The correct answer is option c). "Defective enzymes result in the accumulation of potentially toxic substances".

Step-by-step explanation:

Lysosomal storage diseases (LSDs) are a group of rare metabolic disorders that have a genetic influence and are, most of time, autosomal recessively inherited. The molecular basis of the diseases are an accumulation of potentially toxic substances due to the presence of defective enzymes. In fact, LSDs are often triggered by a single defective enzyme that is required for lipids metabolism.