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Non-disjunction is the failure of homologous chromosomes to separate during meiosis I, or the failure of sister chromatids to separate during meiosis II or mitosis. As a result, both homologous chromosomes or both sister chromatids migrate to the same pole of the cell. This produces daughter cells with an imbalance of chromosomes. If 22 pairs of homologous chromosomes segregate normally during meiosis I in humans (n=23) but we have non-disjunction of 1 pair, then at the end of meiosis II we will have:

User Tenza
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Final answer:

Nondisjunction can occur during either meiosis I or II, resulting in an abnormal chromosome number. If homologous chromosomes fail to separate during meiosis I, the result is two gametes that lack that chromosome and two gametes with two copies of the chromosome. If sister chromatids fail to separate during meiosis II, the result is one gamete that lacks that chromosome, two normal gametes with one copy of the chromosome, and one gamete with two copies of the chromosome.

Step-by-step explanation:

Nondisjunction can occur during either meiosis I or II, resulting in an abnormal chromosome number. If homologous chromosomes fail to separate during meiosis I, the result is two gametes that lack that chromosome and two gametes with two copies of the chromosome. If sister chromatids fail to separate during meiosis II, the result is one gamete that lacks that chromosome, two normal gametes with one copy of the chromosome, and one gamete with two copies of the chromosome.

User Mike Gleason
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Answer: 22 pairs + 3 sex chromosomes =47 chromosomes

Explanation: This is a trisomic disorder

User RDroid
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