Final answer:
Active transport requires ATP to move substances against their concentration gradient, while facilitated diffusion uses specific proteins to move substances along the concentration gradient without requiring energy.
Step-by-step explanation:
A major difference between facilitated diffusion and active transport is that active transport moves substances against the concentration gradient and requires energy, usually in the form of ATP, whereas facilitated diffusion moves molecules along the concentration gradient and does not require cellular energy.
Facilitated diffusion uses proteins such as channels and carriers to allow specific molecules to pass through the plasma membrane based on the concentration gradient, and it is considered a passive form of transport. In contrast, active transport is a process where cells use ATP to drive the movement of molecules against their concentration gradient, through membrane proteins known as pumps.